U.S. Federal Route 45 is a north-south highway in Central Graves County. It runs along the Julian M. Carroll Purchase Parkway to near Mayfield. At Mayfield it runs to the Graves/Mc Cracken County. U.S. Rt. 45 passes through the following towns in Graves County. Water Valley
Mayfield U.S. Rt. 45 is multi-plexed in Graves County. Kentucky State Route 94, from the Graves/Hickman County Line to Water Valley.