U.S. Federal Route 45 is a north-south highway in Central Graves County. It runs along the Julian M. Carroll Purchase Parkway to near Mayfield. At Mayfield it runs to the Graves/Mc Cracken County. U.S. Rt. 45 passes through the following towns in Graves County. Water Valley
Wingo
Pryorsburg
Mayfield U.S. Rt. 45 is multi-plexed in Graves County. Kentucky State Route 94, from the Graves/Hickman County Line to Water Valley.
Branches of U.S. Rt. 45 in Graves County. SB U.S. Rt. 45 at the Graves/Mc Cracken County Line. SB U.S. Rt. 45 near Pittman Road. A junction marker on SB KY Sec St Rt 1241. SB U.S. Rt. 45 at KY Sec St Rt 1276. SB U.S. Rt. 45 north of I-69/Purchase Parkway/BY-PASS U.S. Rt. 45. SB U.S. Rt. 45 at I-69/Purchase Parkway/BY-PASS U.S. Rt. 45. SB U.S. Rt. 45 south of I-69/Purchase Parkway/BY-PASS U.S. Rt. 45. NB U.S. Rt. 45 in Mayfield. SB U.S. Rt. 45 near Harmon Park in Mayfield. SB U.S. Rt. 45 near Ann Street in Mayfield. A BGS on SB I-69/Purchase Parkway/BY-PASS U.S. Rt. 45. A BGS on SB BY-PASS U. S. Rt. 45. SB U.S. Rt. 45/WB KY St Rt 58 south of Mayfield. SB U.S. Rt. 45/WB KY St Rt 58 near Opossum Creek. SB U.S. Rt. 45/WB KY St Rt 58 at Pryorsburg. SB U.S. Rt. 45/WB KY St Rt 58 south of KY Sec St Rt 1748. SB U.S Rt. 45/WB KY St Rt 58 at western KY St Rt 58. SB U.S. Rt. 45 south of KY St Rt 58. SB U.S. Rt. 45 north of Wingo. SB U.S. Rt. 45/EB KY St Rt 339 in Wingo. SB U.S. Rt. 45 south of KY St Rt 339 at Wingo. SB U.S. Rt. 45 south of KY St Rt 944. SB U.S. Rt. 45 near Grissom Road. SB U.S. Rt. 45 north of Water Valley. SB U.S. Rt. 45 near KY Sec St Rt 2422. SB U.S. Rt. 45 in Water Valley. SB U.S. Rt. 45 at KY St Rt 94/KY Sec St Rt 1529.