U.S. Federal Route 61 is a north-south highway in Eastern Winona County. This runs from the Winona/Houston County Line, near La Crescent, to the Winona/Wabasha County Line, near Minneiska. U.S. Rt. 61 passes through the following towns in Winona County. La Moille Homer
Minnesota City U.S. Rt. 61 is multi-plexed in Winona County. U.S. Rt. 14, from the Winona/Houston County Line to Winona.