Business Loop Interstate 57 runs into the City of Charleston in Southeastern Missouri. This is the only spur of Interstate 57 in both Missouri and Illinois. BUSN Loop I-57 passes through the following town in Mississippi County. Charleston BUSN Loop I-57 is multi-plexed in Mississippi County. Missouri State Route 105, near Charleston.
The southern end of BUSN Loop I-57. The southern end marker. A BGS on NB I-57/EB U.S. Rt. 60. NB BUSN Loop I-57/MO St Rt 105 north of I-57/U.S. Rt. 60. NB BUSN Loop I-57/EB U.S. Rt. 62/SB MO St Rt 77 in Charleston. NB BUSN Loop I-57; EB U.S. Rt. 62; SB MO St Rt 77 on the eastside of Charleston.