U.S. Federal Route 60 runs east-west across Northenr Mississippi County. This runs on INterstate 57 from the Scott/Mississippi County Line to near Charleston. From near Charleston to the Missouri/Illinois State Line it runs on a two-lane road. U.S. Rt. 60 passes through the following town in Mississippi County. Birds Point U.S. Rt. 60 is multi-plexed in Mississippi County. Interstate 57, from the Scott/Mississippi County Line to near Charleston.
U.S. Rt. 62, from near Charleston to the Missouri/Illinois State Line.
NB I-57/EB U.S. Rt. 60 near Bertrand. A BGS on NB BUSN Loop I-57/MO St Rt 105. A junction marker on NB BUSN Loop I-57/EB U.S. Rt. 60/SB MO St Rt 77. EB U.S. Rt. 60/62; SB MO St Rt 77 east of I-57. EB U.S. R.t 60/62; SB MO St Rt 77 near MO Sec St Rt J/JJ. EB U.S. Rt. 60/62; SB MO St Rt 77 east of MO Sec St Rt J/JJ. EB U.S. Rt. 60/62 east of MO St Rt 77. EB U.S. Rt. 60/62 near MO Sec St Rt EE. SB U.S. Rt. 60/62 at the Missouri Welcome Sign. NB U.S. Rt. 60/62 at the curve to the Mississippi River Bridge. NB U.S. Rt. 60/62 at the bridge. NB U.S. Rt. 60/62 crossing the Mississippi River.