U.S. Federal Route 62 runs east-west across Northern Mississippi County. This runs along the Interstate 57 corridor. U.S. Rt. 62 passes through the following towns in Mississippi County. Bertrand Charleston Birds Point U.S. Rt. 62 is multi-plexed in Mississippi County. Missouri State Route 77, from near Bertrand to near Wyatt. BUSN Loop I-57, at Charleston.
U.S. Rt. 60, from near Charleston to the Illinois/Missouri State Line.
A junction marker on NB BUSN Loop I-57/MO St Rt 105. NB BUSN Loop I-57/EB U.S. Rt. 62/SB MO St Rt 77 in Charleston. NB BUSN Loop I-57/EB U.S. Rt. 62/SB MO St Rt 77 on the eastside of Charleston. EB U.S. Rt. 60/62; SB MO St Rt 77 east of I-57. EB U.S. R.t 60/62; SB MO St Rt 77 near MO Sec St Rt J/JJ. EB U.S. Rt. 60/62; SB MO St Rt 77 east of MO Sec St Rt J/JJ. EB U.S. Rt. 60/62 east of MO St Rt 77. EB U.S. Rt. 60/62 near MO Sec St Rt EE. SB U.S. Rt. 60/62 at the Missouri Welcome Sign. NB U.S. Rt. 60/62 at the curve to the Mississippi River Bridge. NB U.S. Rt. 60/62 at the bridge. NB U.S. Rt. 60/62 crossing the Mississippi River.