Missouri Secondary State Route E is a north-south highway in West-Central Boone County. It runs from the northwest side of Columbia to near Hallsville. MO Sec St Rt E passes through the following town in Boone County. Columbia
MO Sec St Rt E is not multi-plexed in Boone County. MO Sec St Rt E intersects the following highways in Boone County. Interstate 70, at Columbia. U.S. Rt. 40, at Columbia.