Missouri State Route 240 runs north-south across most of Howard County. It runs from the Boone/Howard County Line, near Rocheport, to the Howard/Saline County Line, near Glasgow. MO St Rt 240 passes through the following towns in Howard County. Fayette
Glasgow MO St Rt 240 is multi-plexed in Howard County. U.S. Rt. 40, near Rocheport.