Missouri State Route 5 is the central most north-south highway in Howard County. It runs from the Cooper/Howard County Line, near Boonville, to the Chariton/Howard County Line, near Glasgow. MO St Rt 5 passes through the following towns in Howard County. Old Franklin
Glasgow MO St Rt 5 is multi-plexed in Howard County. U.S. Rt. 40, near Old Franklin.