Missouri State Route 5 is the central most north-south highway in Howard County. It runs from the Cooper/Howard County Line, near Boonville, to the Chariton/Howard County Line, near Glasgow. MO St Rt 5 passes through the following towns in Howard County. Old Franklin
New Franklin
Franklin Estill
Fayette
Glasgow MO St Rt 5 is multi-plexed in Howard County. U.S. Rt. 40, near Old Franklin.
EB U.S. Rt. 40/NB MO St Rt 5 at Old Franklin. A junction marker on WB U.S. Rt. 40. NB MO St Rt 5 north of U.S. Rt. 40. NB MO St Rt 5 in New Franklin. NB MO St Rt 5 north of Franklin. NB MO St Rt 5 near Estill. NB MO St Rt 5 south of Fayette.