Missouri State Route 364 runs east-west across St. Charles County. It goes from the Missouri River at St. Charles to Interstate 64; U.S. 40/61 at Lake St. Louis. MO St Rt 364 passes through the following towns in St. Charles County. St. Charles
Lake St. Louis MO St Rt 364 is multi-plexed in St. Chrales County. Missouri State Route 94, from St. Charles to St. Peters.