Missouri State Route 5 runs north-south in West-Central Cooper County. It runs from the Cooper/Morgan County Line, near Syracuse, to the Missouri River Bridge, at Boonville. MO St Rt 5 passes through the following towns in Cooper County. Bellair Boonville
MO St Rt 5 is multi-plexed in Cooper County. BUSN Loop I-70, at Boonville. U.S. Rt. 40, at Boonville.
MO St Rt 5 intersects the following highways in Cooper County. Missouri Secondary State Route PP, near Syracuse. Missouri Secondary State Route E, near Bellair. Missouri Secondary State Route J, near Bellair. Missouri Secondary State Route F, at Bellair. Interstate 70, near Boonville. BUSN Loop I-70, near Boonville. U.S. Rt. 40, near Boonville.
WB U.S. Rt. 40/SB MO St Rt 5-87 in Boonville. A junction marker on WB BUSN Loop I-70/NB MO St Rt 87. WB BUSN Loop I-70/U.S. Rt. 40; SB MO St Rt 5 west of Boonville. WB BUSN Loop I-70/U.S. Rt. 40; SB MO St Rt 5 near I-70. A BGS on EB I-70/U.S. Rt. 40.
