U.S. Federal Route 60 runs breifly through Northern New Madrid County. This is a four-lane highway through the entire length of the county. It by-passes the Sikeston-Miner Area. U.S. Rt. 60 does not pass through any towns in New Madrid County. U.S. Rt. 60 is not multi-plexed in New Madrid County. U.S. Rt. 60 intersects the following highways in New Madrid County. Missouri Secondary State Route E, near Morehouse.