U.S. Federal Route 60 runs breifly through Northern New Madrid County. This is a four-lane highway through the entire length of the county. It by-passes the Sikeston-Miner Area. U.S. Rt. 60 does not pass through any towns in New Madrid County. U.S. Rt. 60 is not multi-plexed in New Madrid County. U.S. Rt. 60 intersects the following highways in New Madrid County. Missouri Secondary State Route E, near Morehouse.
Branches of U.S. Rt. 60 in New Madrid County. EB U.S. Rt 60 east of the New Madrid/Stoddard County Line. A BGS on SB U.S. Rt. 61/WB U.S. Rt. 62. EB U.S. Rt. 60 east of U.S. Rt. 61/62; BUSN U.S. Rt. 60.
