U.S. Federal Route 61 runs north-south through New-Madrid County. This one of few surface highways to span the length of the county. U.S. Rt. 61 passes through the following highways in New Madrid County. Sikeston New Madrid
Howardville Marston Portageville U.S. Rt. 61 is multi-plexed in New Madrid County. U.S. Rt. 62, from the Scott/New Madrid County Line to near Howardville.
Interstate 55, near New Madrid. BUSN Loop I-55, near New Madrid. Missouri Secondary State Route D, near Howardville. U.S. Rt. 62, near Howardville. Missouri Secondary State Route EE, near Marston. Missouri Secondary State Route EE, at Marston. Missouri Secondary State Route M, near Conran. Missouri Secondary State Route F, near Conran. Missouri State Route 162, at Portageville. Missouri Secondary State Route T, at Portageville. Interstate 55, near Portageville. Missouri State Route 162, near Portageville.
SB U.S. Rt. 61/WB U.S. Rt. 62/EB BUSN U.S. Rt. 60 near the Scott/New Madrid County Line.
SB U.S. Rt. 61/WB U.S. Rt. 62/EB BUSN U.S. Rt. 60 near U.S. Rt. 60.
A BGS on WB U.S. Rt. 60.
BGS on SB I-55.
Another BGS on SB I-55.
SB U.S. Rt. 61/WB U.S. Rt. 62/SB BUSN Loop I-55 north of New Madrid.
SB U.S. Rt. 61/WB U.S. Rt. 62/BUSN Loop I-55 in New Madrid.