U.S. Federal Route 62 runs north-south through New-Madrid County. This one of few surface highways to span the length of the county. U.S. Rt. 61 passes through the following highways in New Madrid County. Sikleston New Madrid
Howardville Marston Risco U.S. Rt. 62 is multi-plexed in New Madrid County. BUSN U.S. Rt. 60, at Sikeston.
U.S. Rt. 61, from the Scott/New Madrid County Line to near Howardville.
Interstate 55, near New Madrid. BUSN Loop I-55, near New Madrid. Missouri Secondary State Route D, near Howardville. U.S. Rt. 61, near Howardville. Missouri Secondary State Route W, near Catron. Missouri State Route 153, at Risco. Missouri Secondary State Route NN, near Malden. Missouri Secondary State Route J, near Malden.
SB U.S. Rt. 61/WB U.S. Rt. 62/EB BUSN U.S. Rt. 60 in Sikeston. SB U.S. Rt. 61/WB U.S. Rt. 62/EB BUSN U.S. Rt. 60 near U.S. Rt. 60. A BGS on WB U.S. Rt. 60. BGS on SB I-55. Another BGS on SB I-55. SB U.S. Rt. 61/WB U.S. Rt. 62/SB BUSN Loop I-55 north of New Madrid. SB U.S. Rt. 61/WB U.S. Rt. 62/BUSN Loop I-55 in New Madrid.
