U.S. Federal Route 63 runs the entire length of Boone County. It bypasses Columbia to the east. This is the main link between Columbia, and Jefferson City. U.S. Rt. 63 passes through the following town in Boone County. Columbia
NB U.S. Rt. 63 near a railroad crossing north of MO Sec St Rt B in Columia. NB U.S. Rt. 63 at the second crossing warning signs. NB U.S. Rt. 63 at the railroad crossing. SB U.S. Rt. 63 near MO Sec St Rt PP. A BGS on WB I-70/U.S. Rt. 40. A BGS on EB I-70/U.S. Rt. 40. A BGS on EB I-70/U.S. Rt. 40. A BGS on WB MO Sec St Rt WW. A BGS on EB MO Sec St Rt AC. SB U.S. Rt. 63 near Pierpont. SB U.S. Rt. 63 near Ashland. SB U.S. Rt. 63 at Ashland. A junction marker on EB MO Sec St Rt M. A junction marker on WB MO Sec St Rt Y. SB U.S. Rt. 63 near Hartsburg. SB U.S. Rt. 63 near the Boone/Callaway County Line.