New Jersey State Route 49 is a north-south highway in Western Salem County. This runs along the eastern shore of the Delaware River. It runs from Interstate 295/New Jersey Turnpike/U.S. Rt 40-130, at Deepwater, to the Salem/Cumberland County Line, near Shiloh. NJ St Rt 49 passes through the following towns in Salem County. Salem Deepwater NJ St Rt 49 is not multi-plexed in Salem County. NJ St Rt 49 intersects the following highways in Salem County. New Jersey State Route 45, at Salem. Intrerstate 295, at Deepwater. New Jersey Turnpike, at Deepwater. U.S. Rt. 40, at Deepwater. U.S. Rt. 130, at Deepwater.