U.S. Federal Route 1 is a north-south across Central Middlesex County. It is a divided highway the entire length. U.S. Rt. 1 passes through the following towns in Middlesex County. Avenel Edison Stelton Highland Park New Brunswick Milltown North Brunswick U.S. Rt. 1 is multi-plexed in Middlesex County. U.S. Rt. 9, near Avenel. U.S. Rt. 1 intersects the following highways in Middlesex County. New Jersey State Route 35, at Avenel. U.S. Rt. 9, near Avenel. Garden State Parkway, near Menlo Park. Interstate 287, near Edison. New Jersey State Route 18, near New Brunswick. U.S. Rt. 130, near Milltown. New Jersey State Route 171, near Milltown. New Jersey State Route 26, near Milltown. New Jersey State Route 91, near North Brunswick.