U.S. Federal Route 25 runs north-south Central Henderson County. It runs from the North Carolina/South Carolina State Line, near Travelers Rest, South Carolina, to the Henderson/Buncombe County Line, near Oak Park. U.S. Rt. 25 passes through the following towns in Henderson County. Tuxedo Zirconia Hendersonville Mountain Home Fletcher U.S Rt. 25 is multi-plexed in Henderson County. Interstate 26, from near East Flat Rock to Fletcher. U.S. Rt. 74, from near East Flat Rock to Fletcher.
Branches of U.S. Rt. 25 in Henderson County. A BGS on WB I-26/U.S. Rt. 74. A BGS on WB I-26/U.S. Rt. 74. WB I-26/U.S. Rt. 74; NB U.S. Rt. 25 at Upward Road. WB I-26/U.S. Rt. 74; NB U.S. Rt. 25 north of Upward Road. WB I-26/U.S. Rt. 74; NB U.S. Rt. 25 at U.S. Rt. 64. A BGS on WB I-26/U.S. Rt. 74TRUCK U.S. Rt. 64; NB U.S. Rt. 25. A BGS on WB I-26/U.S. Rt. 74TRUCK U.S. Rt. 64; NB U.S. Rt. 25.