U.S. Federal Route 74 runs north-south in Henderson County. It runs from Polk/Henderson County Line, near Saluda, to the Henderson/Buncombe County Line, near Fletcher. U.S. Rt. 74 passes through the following towns in Henderson County. HendersonvilleU.S. Rt. 74 is multi-plexed in Henderson County. Interstate 26, throughout Henderson County. U.S. Rt. 25, from Hendersonville to Fletcher.