U.S. Federal Route 50 runs through Downtown Cincinnati. Through the central and western portion of the county it runs along the Ohio River. U.S. Rt. 50 passes through the following towns in Hamilton County. Cleves Addyston Cincinnati Fairfax Mariemont Terrace Park U.S. Rt. 50 is multi-plexed in Hamilton County. Interstate 75, at Cincinnati. Interstate 71, at Cincinnati.