U.S. Federal Route 52 is a east-west highway through Hamilton County. Much of this runs on the expressway system of Greater-Cincinnati. U.S. Rt. 52 passes through the following towns in Hamilton County. Harrison Cincinnati
U.S. Rt. 52 is multi-plexed in Hamilton County. Interstate 74, from the Ohio/Indiana State Line to Cincinnati.
EB I-74/U.S. Rt. 52 at the Ohio Welcome Sign. (October, 2017) EB I-74/U.S. Rt. 52 at the Ohio Welcome Sign. (March, 2022) WB I-74/U.S. Rt. 52 west of New Haven Road. WB I-74/U.S. Rt. 52 at New Haven Road. EB I-74/U.S. Rt. 52 near New Haven Road. EB I-74/U.S. Rt. 52 near West Road. EB I-74/U.S. Rt. 52 at Dry Fork. EB I-74/U.S. Rt. 52 east of Dry Fork Road. EB I-74/U.S. Rt. 52 west of I-275. WB I-74/U.S. Rt. 52 west of I-275. WB I-74/U.S. Rt. 52 west of I-275. EB I-74/U.S. Rt. 52 at I-275. A BGS on NB I-275. NB I-275; EB I-74/U.S. Rt. 52 near Miamitown. WB I-74/U.S. Rt. 52; SB I-275 at south I-275. WB I-74/U.S. Rt. 52; SB I-275 near south I-275. WB I-74/U.S. Rt. 52; SB I-275 west of OH St Rt 128. EB I-74/U.S. Rt. 52; NB I-275 at OH St Rt 128. (July, 2019) EB I-74/U.S. Rt. 52; NB I-275 at OH St Rt 128. (March, 2022) A BGS on NB OH St Rt 128. A guide marker on SB OH St Rt 128. A junction marker on SB OH St Rt 128. A guide marker on SB OH St Rt 128. EB I-74/U.S. Rt. 52; NB I-275 east of OH St Rt 128. EB I-74/U.S. Rt. 52; NB I-275 west of north I-275. EB I-74/U.S. Rt. 52; NB I-275 at north I-275. EB I-74/U.S. Rt. 52 east of Harrison Ave. EB I-74/U.S. Rt. 52 east of Harrison Ave. EB I-74/U.S. Rt. 52 east of Bend Road. EB I-74/U.S. Rt. 52 west of U.S. Rt. 27. EB I-74/U.S. Rt. 52 at north U.S. Rt. 27. EB I-74/U.S. Rt. 52 at north U.S. Rt. 27. EB I-74/U.S. Rt. 52; SB U.S. Rt. 27 east of Beekman Street. EB I-74/U.S. Rt. 52; SB U.S. Rt. 27 near Mill Creek. A BGS on EB I-74/U.S. Rt. 52; SB U.S. Rt. 127. NB I-75/WB U.S. Rt. 52 near Bank Street in Cincinnati. A BGS on NB I-75/WB U.S. Rt. 52. A BGS on SB I-75/U.S. Rt. 27; EB U.S. Rt. 52. NB I-75/WB U.S. Rt. 52 at Hopple Street in Cincinnati. NB U.S. Rt. 27; WB U.S. Rt. 52/TK U.S. Rt. 50 near Great American Ball Park. BGS in Downtown Cincinnati.