Business U.S. Federal Route 22 runs east-west in East-Central Allegheny County. It runs from Interstate 376/U.S. Rt. 22, near Churchill, to Interstate 76/376; U.S. Rt. 22, at Monroeville. BUSN U.S. Rt. 22 passes through the following towns in Allegheny County. Churchill Monroeville BUSN U.S. Rt. 22 is not multi-plexed in Allegheny County. BUSN U.S. Rt. 22 intersects the following highways in Allegheny County. Interstate 376, at Churchill. U.S. Rt. 22, at Churchill. Pennsylvania State Route 791, at Churchill. Pennsylvania State Route 48, at Monroeville. Interstate 76, at Monroeville. Interstate 376, at Monreville. Pennsylvania Turnpike, at Monroeville. U.S. Rt. 22, at Monroeville.