U.S. Federal Route 22 runs along a expressway through Allegheny County, except for a short segment between the junction with Interstate 376 and the Allegheny/Westmoreland County Line. U.S. Rt. 22 passes through the following town in Allegheny County. Pittsburgh U.S. Rt. 22 is multi-plexed in Allegheny County. U.S. Rt. 30, from near Imperial to near Edgewood. Interstate 376, from near Carnegie to Monroeville. U.S. Rt. 19, at Pittsburgh. Truck U.S. Rt. 19, at Pittsburgh. U.S. Rt. 22 crosses the following highways in Allegheny County. Interstate 376,U.S. Rt. 30, near Imperial. Pennsylvania State Route 978, near Imperial. Pennsylvania State Route 60, near Gayly. Interstate 79, near Carnegie. Pennsylvania State Route 50, near Carnegie. Pennsylvania State Route 121, near Green Tree. U.S. Rt. 19, at Pittsburgh. U.S. Rt. 19, at Pittsburgh. TRUCK U.S. Rt. 19, at Pittsburgh. Pennsylvania State Route 51, at Pittsburgh. Pennsylvania State Route 837, at Pittsburgh. Interstate 279, at Pittsburgh. TRUCK U.S. Rt. 19, at Pittsburgh. Interstate 579, at Pittsburgh. Pennsylvania State Route 885, at Pittsburgh. U.S. Rt. 30, at Edgewood. Pennsylvania State Route 8, near Edgewood. Pennsylvania State Route 130, near Churchill. (NO INTERCHANGE) BUSN U.S. Rt. 22, near Rodi. Pennsylvania State Route 791, near Rodi. Interstate 376, near Monroeville. BUSN U.S. Rt. 22, near Monroeville. Interstate 76, (Pennsylvania Turnpike) near Monroeville. (NO INTERCHANGE) Pennsylvania State Route 286, near Murryville.
Branches of U.S. Rt. 22 in Allegheny County. A set of BGS's on NB I-79. EB I-376; EB U.S. Rt. 22/30 near Carnegie. EB I-376; EB U.S. Rt. 22/30 near Mansfield Ave. EB I-376; EB U.S. Rt. 22/30 near Green Tree. Looking west down I-376; U.S. Rt. 22/30 from the gold tower in the picture above in Green Tree. I-376; U.S. Rt. 22/30 passes through steep grades near Downtown Pittsburgh. The first warning sign for the Fort Pitt Tunnel on EB I-376; EB U.S. Rt. 22/30. A sign for a truck run-away ramp on EB I-279; EB U.S. Rt. 22/30. EB I-376/U.S. Rt. 19; EB U.S. Rt. 22/30 near the Fort Pitt Tunnel. Lane markers near the Fort Pitt Tunnel. EB I-376/TK U.S. Rt. 19; EB U.S. Rt. 22/30 at the Fort Pitt Tunnel. EB I-376/TK U.S. Rt. 19; EB U.S. Rt. 22/30 in the Fort Pitt Tunnel. EB I-376/TK U.S. Rt. 19; EB U.S. Rt. 22/30 crossing the Monongahela River.
