Roads of the Mid-South & West > Highways of the Commonwealth of Pennsylvania > U.S. Federal Route 222, Pennsylvania > U.S. Federal Route 222; Lancaster County, Pennsylvania

U.S. Federal Route 222
Lancaster County

U.S. Federal Route 222 is a north-south highway in Central Lancaster County. It runs from the Pennsylvania/Maryland State Line, near Oakwood, Maryland, to the Lancaster/Berks County Line, near Knauers.
U.S. Rt. 222 passes through the following towns in Lancaster County.
New Texas
Wakefield
Penn Hill
Quarryville
New Providence
Refton
Lyndon
Lancaster

Brownstown
U.S. Rt. 222 is multi-plexed in Lancaster County.
Pennsylvania State Route 272, from Wakefield to Penn Hill.
Pennsylvania State Route 372, at Quarryville.
Pennsylvania State Route 741, at Willow Street.
Pennsylvania State Route 272, from Willow Street to Lancaster.
Pennsylvania State Route 501, at Lancaster.
U.S. Rt. 30, at Lancaster.
U.S. Rt. 222 crosses the following highways in Lancaster County.
Pennsylvania State Route 272, at Wakefield.
Pennsylvania State Route 272, at Penn Hill.
Pennsylvania State Route 372, at Quarryville.
Pennsylvania State Route 372, at Quarryville.
Pennsylvania State Route 741, near Lampeter.
Pennsylvania State Route 272, at Willow Street.
Pennsylvania State Route 741, at Willow Street.
Pennsylvania State Route 324, at Lancaster.
Pennsylvania State Route 72, at Lancaster.
Pennsylvania State Route 462, at Lancaster.
Pennsylvania State Route 23, at Lancaster.
Pennsylvania State Route 501, at Lancaster.
U.S. Rt. 30, at Lancaster.
Pennsylvania State Route 272, at Lancaster.
Pennsylvania State Route 283, at Lancaster.
Pennsylvania State Route 501, at Lancaster.
Pennsylvania State Route 722, at Oregon.
Pennsylvania State Route 772, at Brownsville.
U.S. Rt. 322, near Murrell.
Interstate 76, near Swartzville.
Pennsylvania Turnpike, near Swartzville.
Pennsylvania State Route 897, near Swartzville. (NO Interchange)

A VMB on WB I-76/PA Turn.

A BGS on EB I-76/PA Turn.

A BGS on EB I-76/PA Turn.

A BGS on WB I-76/PA Turn.

A guide marker in Lancaster.

NB U.S. Rt. 222/PA St Rt 272 near Oregon Pike.

A guide marker on NB U.S. Rt. 222/PA St Rt 272.

NB U.S. Rt. 222/PA St Rt 272 near Marshall Ave.

NB U.S. Rt. 222/PA St Rt 272 near Mc Govern Ave.

A guide marker in Lancaster.

A guide marker on Harrisburg Ave.

SB U.S. Rt. 222/PA St Rt 272 near Chestnut.

SB U.S. Rt. 222/PA St Rt 272 near King Street.
21=5 October 2025