South Carolina State Route 133 runs north-south in Western Pickens County. It goes from U.S. Rt. 76/123; South Carolina State Route 28, at Clemson, to South Carolina State Route 11, at the Keowee Toxaway State Park. SC St Rt 133 passes through the following towns in Pickens County. Clemson Six Mile SC St Rt 133 is multi-plexed in Pickens County. South Carolina State Route 137, at Six Mile. SC St Rt 133 intersects the following highways in Pickens County. U.S. Rt. 76, at Clemson. U.S. Rt. 123, at Clemson. South Carolina State Route 28, at Clemson.
A junction marker on EB U.S. Rt. 76/SC St Rt 28; NB U.S. Rt. 123. A guide marker on EB U.S. Rt. 76/SC St Rt 28; NB U.S. Rt. 123. A guide marker on EB U.S. Rt. 76/SC St Rt 28; NB U.S. Rt. 123.
