U.S. Federal Route 76 is a north-south highway in Southwestern Pickens County. It runs from the Oconee/Pickens County Line, near Clemson, to the Anderson/Pickens County Line, near Anderson. U.S. Rt. 76 passes through the following town in Pickens County. Clemson U.S. Rt. 76 is multi-plexed in Pickens County. U.S. Rt. 123, at Clemson. South Carolina State Route 28, throughout Pickens County.
U.S. Rt. 123, at Clemson. South Carolina State Route 93, at Clemson. BUSN South Carolina State Route 28, at Clemson.
EB U.S. Rt. 76/SC St Rt 28; NB U.S. Rt. 123 at the Oconee/Pickens County Line. EB U.S. Rt. 76/SC St Rt 28; NB U.S. Rt. 123 near Keowee Trail. A BGS on EB U.S. Rt. 76/SC St Rt 28; NB U.S. Rt. 123. EB U.S. Rt. 76/SC St Rt 28; NB U.S. Rt. 123 east of Stoney Creek Lane. A guide marker on EB U.S. Rt. 76/SC St Rt 28; NB U.S. Rt. 123.
