Tennessee State Route 216 is an east-west highway in Northwestern Weakley County. It runs from the Obion/Weakley County Line, near Rives, to U.S. Rt. 45E/Tennessee State Route 22/Tennessee State Route 431, at Ralston. The section from Tennessee State Route 43 on the southwest side of Martin to the eastern end point in Ralston is unsigned. TN St Rt 216 passes through the following towns in Weakley County. Martin
A junction marker on SB TN St Rt 43. A guide marker on SB TN St Rt 43. SB TN St Rt 43/EB TN St Rt 216 at Baker Road. SB TN St Rt 43/EB TN St Rt 216 west of U.S. Rt. 45E/BUSN U.S. Rt. 45E/TN St Rt 372. NB U.S. Rt. 45E/EB TN St Rt 216 east of BUSN U.S. Rt. 45E; TN St Rt 43/216. NB U.S. Rt. 45E/EB TN St Rt 216 at Pair Road. NB U.S. Rt. 45E/EB TN St Rt 216 south of TN St Rt 22/431.