U.S. Federal Route 45E runs north-south in Western Weakley County. It runs from the Obion/Weakley County Line, near Mc Connell, to the Weakley/Gibson County Line, near Bradford. Most of U.S. Rt. 45E is mutli-lanes and has been constructed to by-pass the city centers of those it passes through. U.S. Rt. 45E passes through the following towns in Weakley County. Martin
Branches of U.S. Rt. 45E in Weakley County. SB U.S. Rt. 45E/TN St Rt 43 at the Obion/Weakley County Line. SB U.S. Rt. 45E/TN St Rt 372 south of TN St Rt 43. SB U.S. Rt. 45E/TN St Rt 372 north of TN St Rt 22. SB U.S. Rt. 45E/TN St Rt 372 at TN St Rt 22. A BGS on SB U.S. Rt. 45E/TN St Rt 372. A BGS on SB U.S. Rt. 45E/TN St Rt 372. A BGS on WB TN St Rt 431. NB U.S. Rt. 45E/EB TN St Rt 216 south of TN St Rt 22/431. A BGS on NB U.S. Rt. 45E/EB TN St Rt 216. A BGS on NB U.S. Rt. 45E/EB TN St Rt 216. NB U.S. Rt. 45E/EB TN St Rt 216 at Pair Road. NB U.S. Rt. 45E/EB TN St Rt 216 east of BUSN U.S. Rt. 45E; TN St Rt 43/372. A BGS on SB TN St Rt 43/EB TN St Rt 216. A junction marker on SB TN St Rt 43/EB TN St Rt 216. A BGS on SB TN St Rt 43/EB TN St Rt 216.