Tennessee State Route 43 runs north-south in Weakley County. The northern and southern portions of this highway runs unsigned with U.S. Rt. 45E. Around the City of Martin, it is a signed highway. TN St Rt 43 passes through the following towns in Weakley County. Martin
Sharon Greenfield TN St Rt 43 is mutli-plexed in Weakley County. U.S. Rt. 45E, from the Obion/Weakley County Line to near Martin. Tennessee State Route 216, at Martin. U.S. Rt. 45E, from Martin to the Weakley/Gibson County Line. Tennessee State Route 54, from Greenfield to the Gibson/Weakley County Line. TN St Rt 43 intersects the following highways in Weakley County. U.S. Rt. 45E, near Martin.