U.S. Federal Route 441 runs north-south though Knox County. This is one of the main highways in Downtown Knox County. U.S. Rt. 441 passes through the following towns in Knox County. Halls Crossroads Knoxville U.S. Rt. 441 is multi-plexed in Knoxville. Tennessee State Route 71, in Knox County. Tennessee State Route 33, near Knoxville.