Illinois State Route 49 cuts north-south through Central Iroquois County. This is also the northern most county that IL St Rt 49 runs through. IL St Rt 49 passes through the following towns in Iroquois County. Cresent City
IL St Rt 49 is not multi-plexed in Iroquois County. IL St Rt 49 intersects the following routes in Iroquois County. U.S. Rt. 45 near L'Erable. U.S. Rt. 52 near L'Erable.