U.S. Federal Route 45 runs north-south in Iroquois County. This highway runs mostly long the eastside of Interstate 57. It provides a more scenic alternative to the interstate highway. U.S. Rt. 45 passes through the following towns in Iroquois County. Ashkum
Danforth
Gilman
Onarga
Del Rey
Buckley
Loda
U.S. Rt. 45 is multi-plexed in Iroquois County. U.S. Rt. 52, from the Iroquois/Kankakeee County Line to near L' Erable.
SB U.S. Rt. 45/EB U.S. Rt. 52 at the Iroquois/Kankakee County Line. SB U.S. Rt. 45/EB U.S. Rt. 52 at the Iroquois/Kankakee County Line. (August, 2018) NB U.S. Rt. 45/WB U.S. Rt. 52 near Clifton. SB U.S. Rt. 45/EB U.S. Rt. 52 near E 2900N Rd. SB U.S. Rt. 45/EB U.S. Rt. 52 near L'erable. NB U.S. Rt. 45/WB U.S. Rt. 52 north of IL St Rt 49. NB U.S. Rt. 45/WB U.S. Rt. 52 north of IL St Rt 49. SB U.S. Rt. 45/EB U.S. Rt. 52 at IL St Rt 49. A junction marker on WB U.S. Rt. 52. A junction marker on NB IL St Rt 49. A junction marker on NB IL St Rt 49. A set of guide markers on NB IL St Rt 49. NB U.S. Rt. 45 near IL St Rt 49. SB U.S. Rt. 45 west of U.S. Rt. 52/IL St Rt 49. NB U.S. Rt. 45 east of Ashkum. NB U.S. Rt. 45 east of Ashkum. NB U.S. Rt. 45 south of IL St Rt 116. SB U.S. Rt. 45 south of Ashkum. SB U.S. Rt. 45 south of Ashkum. NB U.S. Rt. 45 north of Danforth. NB U.S. Rt. 45 north of Danforth. NB U.S. Rt. 45 on the southside of Danforth. SB U.S. Rt. 45 south of Danforth. SB U.S. Rt. 45 south of Danforth. SB U.S. Rt. 45 north of Gilman. NB U.S. Rt. 45 north of Gilman. NB U.S. Rt. 45 north of Gilman. SB U.S. Rt. 45 north of U.S. Rt. 24. SB U.S. Rt. 45 north of U.S. Rt. 45. EB U.S. Rt. 24/NB U.S. Rt. 45 on the eastside of Gilman. A junction marker on EB U.S. Rt. 24/NB U.S. Rt. 45. EB U.S. Rt. 24/NB U.S. Rt. 45 in Gilman. NB U.S. Rt. 45 on the southern side of Gilman. SB U.S. Rt. 45 south of Gilman. SB U.S. Rt. 45 on the south end of Gilman. NB U.S. Rt. 45 north of Onarga. SB U.S. Rt. 45 near Onarga. A junction marker on NB IL St Rt 54. NB U.S. Rt. 45 in Onarga. SB U.S. Rt. 45 south of Onarga. SB U.S. Rt. 45 near Del Rey. NB U.S. Rt. 45 north of Buckley. SB U.S. Rt. 45 north of Buckley. SB U.S. Rt. 45 in Buckley. SB U.S. Rt. 45 south of Buckley. NB U.S. Rt. 45 north of Loda. NB U.S. Rt. 45 in Loda. NB U.S. Rt. 45 at the Ford/Iroquois County Line.
