U.S. Federal Route 45 runs north-south in Iroquois County. This highway runs mostly long the eastside of Interstate 57. It provides a more scenic alternative to the interstate highway. U.S. Rt. 45 passes through the following towns in Iroquois County. Ashkum
Danforth
Gilman
Onarga
Del Rey
Buckley
Loda
U.S. Rt. 45 is multi-plexed in Iroquois County. U.S. Rt. 52, from the Iroquois/Kankakeee County Line to near L' Erable.
NB U.S. Rt. 45/WB U.S. Rt. 52 near Clifton. NB U.S. Rt. 45/WB U.S. Rt. 52 north of IL St Rt 49. A junction marker on WB U.S. Rt. 52. A junction marker on NB IL St Rt 49. A set of guide markers on NB IL St Rt 49. NB U.S. Rt. 45 near IL St Rt 49. NB U.S. Rt. 45 north of Danforth. NB U.S. Rt. 45 on the southside of Danforth. SB U.S. Rt. 45 north of Gilman. NB U.S. Rt. 45 north of Gilman. A junction marker on EB U.S. Rt. 24/NB U.S. Rt. 45. EB U.S. Rt. 24/NB U.S. Rt. 45 in Gilman. NB U.S. Rt. 45 on the southern side of Gilman. SB U.S. Rt. 45 south of Gilman. SB U.S. Rt. 45 near Onarga. A junction marker on NB IL St Rt 54. NB U.S. Rt. 45 in Onarga. SB U.S. Rt. 45 south of Onarga. SB U.S. Rt. 45 near Del Rey. SB U.S. Rt. 45 north of Buckley. SB U.S. Rt. 45 in Buckley. SB U.S. Rt. 45 south of Buckley.