U.S. Federal Route 45 runs north-south in Iroquois County. This highway runs mostly long the eastside of Interstate 57. It provides a more scenic alternative to the interstate highway. U.S. Rt. 45 passes through the following towns in Iroquois County. Ashkum
U.S. Rt. 45 is multi-plexed in Iroquois County. U.S. Rt. 52, from the Iroquois/Kankakeee County Line to near L' Erable.