U.S. Federal Route 52 runs east-west through the northeastern corner of Iroquois County. U.S. Rt. 52 passes through the following towns in Iroquois County. Effner
Sheldon
Iroquois
Donovan
U.S. Rt. 52 is multi-plexed in Iroquois County. U.S. Rt. 24, from the Indiana/Illinois State Line to Sheldon.
U.S. Rt. 45, from near L' Erable to the Kankakee/Iroquois County Line.
U.S. Rt. 52 intersects the following highways in Iroquois County. U.S. Rt. 24, at Sheldon.
EB U.S. Rt. 24/52 near the Illinois/Indiana State Line. WB U.S. Rt. 24/52 at Effner. WB U.S. Rt. 24/52 at the Illinois Welcome Sign. A junction marker on WB U.S. Rt. 24/52. A junction marker on WB U.S. Rt. 24/52. EB U.S. Rt. 24/52 east of Sheldon. EB U.S. Rt. 24/52 east of Sheldon. WB U.S. Rt. 52 north of U.S. Rt. 24. EB U.S. Rt. 52 at west U.S. Rt. 24. EB U.S. Rt. 52 south of Iroquois. WB U.S. Rt. 52 north of Iroquois. WB U.S. Rt. 52 near Donovan. Here two lines of the Kankakee, Beaverville, and Southern Railroad cross. EB U.S. Rt. 52 south of Donovan. EB U.S. Rt. 52 north of Donovan. EB U.S. Rt. 52 near a railroad crossing north of Donovan. EB U.S. Rt. 52 east of IL St Rt 1. WB U.S. Rt. 52 east of IL St Rt 1. EB U.S. Rt. 52 at IL St Rt 1. WB U.S. Rt. 52 west of IL St Rt 1. EB U.S. Rt. 52 near 1900E Road. EB U.S. Rt. 52 east of IL St Rt 49. EB U.S. Rt. 52 east of U.S. Rt. 45/IL St Rt 49. WB U.S. Rt. 52 near L' Erable. A junction marker on NB U.S. Rt. 45. A junction marker on NB IL St Rt 49. A junction marker on NB IL St Rt 49. A set of guide markers on NB IL St Rt 49. SB U.S. Rt. 45/EB U.S. Rt. 52 at IL St Rt 49. NB U.S. Rt. 45/WB U.S. Rt. 52 north of IL St Rt 49. NB U.S. Rt. 45/WB U.S. Rt. 52 north of IL St Rt 49. SB U.S. Rt. 45/EB U.S. Rt. 52 near L'erable. NB U.S. Rt. 45/EB U.S. Rt. 52 near E 2900N Rd. NB U.S. Rt. 45/WB U.S. Rt. 52 near Clifton. SB U.S. Rt. 45/WB U.S. Rt. 52 at the Kankakee/Iroquois County Line. SB U.S. Rt. 45/WB U.S. Rt. 52 at the Kankakee/Iroquois County Line.
