U.S. Federal Route 36 is a east-west highway across Northern Pike County. It runs along the Central Illinois Expressway (Interstate 72) through Pike County. U.S. Rt. 36 enters Pike County from Missouri on the Mark Twain Bridge and runs east to Scott County. U.S. Rt. 36 does not pass through any towns in Pike County. U.S. Rt. 36 is multi-plexed in Pike County. Interstate 72, across Pike County.