U.S. Federal Route 150 runs north-south in the north-central portion of Knox County. At Vincennes this highway turns and runs east-west. U.S. Rt. 150 passes through the following town in Knox County. Vincennes
U.S. Rt. 150 is multi-plexed in Knox County. U.S. Rt. 41, from the Knox/Sullivan County Line to east of Vincennes.
U.S. Rt. 50, from north of Vincennes to the Knox/Daviess County Line.
U.S. Rt. 150 intersects the following highways in Knox County. Indiana State Route 550, near Maysville.
NB U.S. Rt. 41/WB U.S. Rt. 150 north of Oaktown. NB U.S. Rt. 41/WB U.S. Rt. 150 at Oaktown. NB U.S. Rt. 41/WB U.S. Rt. 150 south of Oaktown. NB U.S. Rt. 41/WB U.S. Rt. 150 north of IN St Rt 550. A junction marker on WB IN St Rt 550. NB U.S. Rt. 41/WB U.S. Rt. 150 at IN St Rt 550. NB U.S. Rt. 41/WB U.S. Rt. 150 north of IN St Rt 67. NB U.S. Rt. 41/WB U.S. Rt. 150 at IN St Rt 67. NB U.S. Rt. 41/WB U.S. Rt. 150 north of west U.S. Rt. 50. A BGS on EB U.S. Rt. 50. A BGS on EB U.S. Rt. 50. A BGS on EB U.S. Rt. 50. NB U.S. Rt. 41/WB U.S. Rt. 150 at WB U.S. Rt. 50. A BGS on NB U.S. Rt. 41; WB U.S. Rt. 50/150. A BGS on NB U.S. Rt. 41; WB U.S. Rt. 50/150. NB U.S. Rt. 41; WB U.S. Rt. 50/150 at Washington in Vincennes. EB U.S. Rt. 50/150; SB U.S. Rt. 41 at the stack on the eastside of Vincennes. A BGS on NB U.S. Rt. 41. A BGS on NB U.S. Rt. 41. A set of guide markers on NB IN St Rt 241. WB U.S. Rt. 50/150 east of IN St Rt 241.
