U.S. Rt. 41 runs north south along the western portion of Knox County. This is a four-lane divided route through the entire county. U.S. Rt. 41 does not pass through any towns in Knox County. U.S. Rt. 41 is multi-plexed in Knox County. U.S. Rt. 150, from the Knox/Sullivan County Line to just east of Vincennes.