U.S. Rt. 50 is the main east-west highway across Knox County. This remains four-lanes through the entire county. U.S. Rt. 50 passes through the following town in Knox County. Vincennes
U.S. Rt. 50 is multi-plexed in Knox County. U.S. Rt. 41, around Vincennes. U.S. Rt. 150, from the northside of Vincennes to the Knox/Daviess County Line.
U.S. Rt. 50 intersects the following highways in Knox County. U.S. Rt. 41, on the northside of Vincennes. U.S. Rt. 150, on the northside of Vincennes. U.S. Rt. 41, on the eastside of Vincennes.
EB U.S. Rt. 50 at the Illinois/Indiana State Line. This is the Wabash River bridge. WB U.S. Rt. 50 at the Wabash River. The Indiana welcome sign. EB IN St Rt 50 at the Indiana Welcome Sign. (December, 2024) BGS for the exits to access the City of Vincennes. Note that these are for U.S. Rt. 41. That is because U.S. Rt. 41 by-passes the most of the city. EB U.S. Rt. 50 east of the Wabash River. WB U.S. Rt. 50 west of Hillcrest Road. EB U.S. Rt. 50 at 6th. EB U.S. Rt. 50 at U.S. Rt. 41/150. EB U.S. Rt. 50 at U.S. Rt. 41/150 on the northside of Vincennes. A BGG on EB U.S. Rt. 50. A BGS on EB U.S. Rt. 50. EB U.S. Rt. 50 at NB U.S. Rt. 41/WB U.S. Rt. 150. A BGS on NB 6th. WB U.S. Rt. 50 at NB U.S. Rt. 41/WB U.S. Rt. 150. A BGS on NB U.S. Rt. 41; WB U.S. Rt. 50/150. A BGS on NB U.S. Rt. 41; WB U.S. Rt. 50/150. NB U.S. Rt. 41; WB U.S. Rt. 50/150 near Washington in Vincennes. EB U.S. Rt. 50/150; at SB U.S. Rt. 41 on the eastside of Vincennes. A BGS on NB U.S. Rt. 41. A BGS on NB U.S. Rt. 41. A set of guide markers on NB IN St Rt 241. WB U.S. Rt. 50/150 east of IN St Rt 241.
