Alternate U.S. Federal Route 41 runs further west in Kentucky than the main line does. From Henderson the route heads south connecting to Madisonville, via Dixon. In the south, ALT. U.S. Rt. 41 heads south from Hopkinsville to Tennessee, while th emain-line heads southeast to near Guthrie. Info on ALT. U.S. Rt. 41 is broken down by county below. Henderson County Webster County
