Alternate U.S. Federal Route 41 runs east-west across Northwestern Hopkins County. This connects several remote areas of the county to Madisonville. ALT U.S. Rt. 41 passes through the following towns in Hopkins County. Madisonville
Manitou Nebo ALT U.S. Rt. 41 is multi-plexed in Hopkins County. Kentucy State Route 630, at Manitou. ALT U.S. Rt. 41 intersects the following highways in Hopkins County. U.S. Rt. 41, at Madisonville. Kentucky State Route 281, near Madisonville.
Kentucky Secondary State Route 1581, at Madisonville. Kentucky Secondary State Route 1178, at Madisonville. Kentucky Secondary State Route 1034, at Madisonville. Kentucky State Route 630, at Manitou. Kentucky State Route 630, at Manitou. Kentucky Secondary State Route 2320, near Manitou. Kentucky State Route 502, at Nebo. Kentucky Secondary State Route 1089, near Nebo. Kentucky Secondary State Route 2280, near Nebo.
A junction marker on NB U.S. Rt. 41. BGS on SB Pennyrile.
