U.S. Federal Route 41 north-south through the center of Hopkins County. It provides a surface alternate to the Pennyrile Parkway. U.S. Rt. 41 passes through the following towns in Hopkins County. Slaughters Hanson
BGS on SB Pennyrile. SB U.S. Rt. 41 near Walnurt in Nortonville. SB U.S. Rt. 41 south of U.S. Rt. 62. NB U.S. Rt. 41 north of U.S. Rt. 62. NB U.S. Rt. 41 north of Nortonville. NB U.S. Rt. 41 north of KY Sec St Rt 2083. NB U.S. Rt. 41 at I-69/Western Kentucky Parkway. NB U.S. Rt. 41 north of KY Sec St Rt 2650. NB U.S. Rt. 41 at KY St Rt 813. A junction marker on NB KY St Rt 813. A guide marker on NB KY St Rt 813. NB U.S. Rt. 41 north of Mortons Gap. NB U.S. Rt. 41 near Barnsley Loop. NB U.S. Rt. 41 near Clark in Earlington. NB U.S. Rt. 41 south of KY Sec St Rt 2171. NB U.S. Rt. 41 north of KY Sec St Rt 2171. NB U.S. Rt. 41 south of KY St Rt 336. NB U.S. Rt. 41 south of Dulin Street in Madisonville. NB U.S. Rt. 41 north of KY St Rt 70. NB U.S. Rt. 41 near Cates in Madisonville. NB U.S. Rt. 41 north of ALT U.S. Rt. 41/KY St Rt 281. NB U.S. Rt. 41 near KY Sec St Rt 1069. NB U.S. Rt. 41 north of Madisonville. NB U.S. Rt. 41 south of KY Sec St Rt 2657. NB U.S. Rt. 41 north of KY Sec St Rt 2657. NB U.S. Rt. 41 south of KY St Rt 862. NB U.S. Rt. 41 north of KY St Rt 862. NB U.S. Rt. 41 south of KY St Rt 260. A junction marker on EB KY St Rt 260.