Kentucky State Route 281 is a north-south highway. This is mostly located in Central and Northeastern Hopkins County. KY St Rt 281 passes through the following town in Hopkins County. Vandetta KY St Rt 281 is not multi-plexed in Hopkins County. KY St Rt 281 intersects the following highways in Hopkins County. ALT U.S. Rt. 41, near Madisonville. U.S. Rt. 41, near Madisonville.
Edward T. Breathitt Pennyrile Parkway, near Madisonville. Kentucky Secondary State Route 2338, near Madisonville. Kentucky State Route 862, near Hanson. Kentucky State Route 260, near Hanson. Kentucky Secondary State Route 1033, at Vandetta. Kentucky State Route 138, near Ashleyburg.
A junction marker on NB U.S. Rt. 41. BGS on SB Pennyrile.
