Kentucky State Route 281 is a north-south highway. This is mostly located in Central and Northeastern Hopkins County. KY St Rt 281 passes through the following town in Hopkins County. Vandetta KY St Rt 281 is not multi-plexed in Hopkins County. KY St Rt 281 intersects the following highways in Hopkins County. ALT U.S. Rt. 41, near Madisonville. U.S. Rt. 41, near Madisonville.