Missouri State Route 80 runs east-west in Northern New Madrid County. This is the western most county that MO St Rt 80 passes thorugh. MO St Rt 80 does not pass thorugh any towns in New Madrid County. MO St Rt 80 is not multi-plexed in New Madrid County. MO St Rt 80 intersects the following highways in New Madrid County. U.S. Rt. 61, near Matthews. U.S. Rt. 62, near Matthews. Interstate 55, near Matthews. Missouri Secondary State Route V, near Matthews. Missouri Secondary State Route AA, near Matthews.
