U.S. Federal Route 42 is a north-south highway in Hamilton County. It runs from the Kentucky/Ohio State Line, in Cincinnati, to the Hamilton/Butler County Line, near Highpoint. U.S. Rt. 42 passes through the following towns in Hamilton County. Cincinnati
The Ohio Welcome Sign on EB U.S. Rt. 42/NB U.S. Rt. 127. EB U.S. Rt. 42/NB U.S. Rt. 127 at the Ohio Welcome Sign. EB U.S. Rt. 42/SB U.S. Rt. 127 at the Ohio River. WB U.S. Rt. 42/SB U.S. Rt. 127 at the Clay Wade Bailey Bridge. A guide marker in Cincinnati. A BGS in Cincinnati. WB U.S. Rt. 42/SB U.S. Rt. 127 at I-71/U.S. Rt. 50. SB U.S. Rt. 42 at Sycamore Street. SB U.S. Rt. 42 at 12th Street. A BGS on NB I-471. A guide marker on EB Dorchester Ave. SB U.S. Rt. 42 at Elsinore Place. A BGS in Cincinnati. NB U.S. Rt. 42 at I-71.