U.S. Federal Route 27 runs north-south through Central Hamilton County. It runs from the Kentucky/Ohio State Line, in Cincinnati, to the Hamilton/Butler County Line, near Ross. U.S. Rt. 27 passes through the following towns in Hamilton County. Cincinnati
Groesbeck Northgate Bevis Dunlap U.S. Rt. 27 is multi-plexed in Hamilton County. U.S. Rt. 52, at Cincinnati.
NB U.S. Rt. 27; WB U.S. Rt. 52/TK U.S. Rt. 50 near Great American Ball Park. A BGS on NB I-75. A BGS on SB I-75/U.S. Rt. 27; EB U.S. Rt. 52. A BGS on EB I-74/U.S. Rt. 52; SB U.S. Rt. 27. EB I-74/U.S. Rt. 52; SB U.S. Rt. 52 near Mill Creek. EB I-74/U.S. Rt. 52; SB U.S. Rt. 52 east of Beekman Street. A BGS on EB I-74/U.S. Rt. 52. A BGS on EB I-74/U.S. Rt. 52. BGS on EB I-275.