Roads of the Mid-South & West > Highways of the Commonwealth of Pennsylvania > Interstate 81, Pennsylavania

Interstate 81

Interstate 81 runs north-south interstate in Central Pennsylvania. It runs from the Pennsylvania/Maryland State Line, near Waynesboro, to the Pennsylvania/New York State Line, near Brookdale. This passes by areas such as Harrisburg, Wilkes-Barre, and Scranton.

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While in Pennsylvania, I-81 is multi-plexed.

I-81 is multi-plexed with...
...U.S. Rt. 322, at Harrisburg.
...U.S. Rt. 6, near Scranton.

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In Pennsylvania, Interstate 81 crosses the following interstates.

Interstate 76, (Pennsylvania Turnpike) near Carlisle. (NO Direct Interchange)

A BGS on NB I-81 for the exit to I-76. (July, 2019)
Interstate 83, near Harrisburg.

NB I-81 over one mile from I-83. (July, 2019)

NB I-81 one mile from I-83. (July, 2019)

NB I-81 near I-83. (July, 2019)

NB I-81 at I-83. (July, 2019)
Interstate 78, near Jonestown.
Interstate 80, near Drums.
Interstate 476, (Pennsylvania Turnpike-NE Ext) near Duryea. (NO Direct Interchange)
Interstate 84, near Scranton.
Interstate 476, (Pennsylvania Turnpike-NE Ext) near Clarks Summit.

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There are no branches of I-81 in Pennsylvania.

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NB I-81 at the Pennsylvania Welcome Sign. (August, 2012)

NB I-81 at the Pennsylvania Welcome Sign. (April, 2025)

A NB guide marker.

A guide marker on NB I-81.

A BGS on WB PA St Rt 16.

A set of guide markers on WB PA St Rt 16.

A BGS on WB I-76/PA Turn.

A BGS on EB I-76/PA Turn. (April, 2025)

A BGS on the ramp from I-76/PA Turn.

A guide marker on NB U.S. Rt. 11.

A junction marker on NB U.S. Rt. 11.

NB I-81 at U.S. Rt. 11.

SB I-81 at U.S. Rt. 11.

NB I-81 north of U.S. Rt. 11.

SB I-81 south of PA St Rt 114.

NB I-81 at PA St Rt 114.

SB I-81 at PA St Rt 114.

NB I-81 north PA St Rt 114.

NB I-81 south of PA St Rt 581.

NB I-81 at PA St Rt 581.

A BGS on WB PA St Rt 581.

A BGS on WB PA St Rt 581.

A BGS on SB I-81.

SB I-81 north of PA St Rt 581.

SB I-81 at PA St Rt 944.

SB I-81 north of PA St Rt 944.

NB I-81 north of PA St Rt 944.

NB I-81 at Tower Road.

NB I-81 south of U.S. Rt. 11/15.

NB I-81 at U.S. Rt. 11/15.

SB I-81 at U.S. Rt. 11/15.

A guide marker in Enola.

NB I-81 at the Susquehanna River.

NB I-81 at Front Street.

SB I-81 at Front Street.

SB I-81 east of U.S. Rt. 22.

A guide marker in Harrisburg.

A BGS on NB I-81.

NB I-81 at U.S. Rt. 22/322.

SB I-81 at U.S. Rt. 22.

SB I-81/WB U.S. Rt. 322 east of U.S. Rt. 22.

SB I-81/WB U.S. Rt. 322 west of I-83.

A guide marker on Derry Street.

A BGS on NB I-283.

A BGS on NB I-83/WB U.S. Rt. 322.

NB I-81 east of I-83/U.S. Rt. 322.

EB I-81 east of Mountain Road.

A guide marker on Mountain Road.

EB I-81 east of Mountain Road.

EB I-81 at PA St Rt 39.

EB I-81 east of PA St Rt 39.

A guide marker on NB PA St Rt 743.

A guide marker on Hershey Park Drive.

A guide marker on NB PA St Rt 743.

A BGS at Hershey Park.

A BGS on WB U.S. Rt. 322.

A BGS on EB I-80.

A BGS on EB I-80.

A BGS on EB I-80.

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15 December 2025