U.S. Federal Route 220 is a north-south highway in Central Bedford County. This highway runs in Bedford County from the Pennsylvania/Maryland State Line, near Ellerslie, Maryland, to the Blair/Bedford County Line, near Claysburg. U.S. Rt. 220 passes through the following towns in Bedford County. Bedford St. Clairsville U.S. Rt. 220 is multi-plexed in Bedford County. Interstate 99, from near Bedford to the Bedford/Blair County Line. U.S. Rt. 220 crosses the following highways in Bedford County. Pennsylvania State Route 303, near Hyndman. BUSN U.S. Rt. 220, Buffalo Mills. U.S. Rt. 30, at Bedford. Interstate 70, near Bedford. (NO Direct Interchange) Interstate 76, near Bedford. (NO Direct Interchange) Interstate 99, near Bedford. Pennsylvania Turnpike, near Bedford. (NO Direct Interchange) Pennsylvania State Route 56, near Bedford. (NO Interchange) BUSN U.S. Rt. 220, near Bedford. Pennsylvania State Route 56, near Bedford. Pennsylvania State Route 896, near St. Clairsville.