U.S. Federal Route 522 is a north-south highway in Eastern Fulton County. It runs from The Maryland/Pennsylvania State Line. near Hancock, Maryland, to the Fulton/Huntingdon County Line, near Burnt Cabins. U.S. Rt. 522 passes through the following towns in Fulton County. Warfordsburg Needmore Big Cove Tannery McConnellsburg Knobsville Fort Littleton Burnt Cabins U.S. Rt. 522 is multi-plexed in Fulton County. Interstate 70, from the Maryland/Pennsylvania State Line to Warfordsburg Pennsylvania State Route 655, near Needmore. U.S. Rt. 522 intersects the following highways in Fulton County. Interstate 70, near Warfordsburg. Pennsylvania State Route 643, near Needmore. Pennsylvania State Route 655, at Needmore. Pennsylvania State Route 655, near Needmore. Pennsylvania State Route 928, at Big Cove Tannery. Pennsylvania State Route 16, at McConnellsburg. U.S. Rt. 30, at McConnellsburg. Pennsylvania State Route 475, near Fort Littleton. Interstate 76, at Fort Littleton. Pennsylvania Turnpike, at Fort Littleton.