South Carolina State Route 28 runs north-south in Central Oconee County. It runs from the Georgia/South Carolina State Line, near Pine Mountain, Georgia, to the Oconee/Pickens County Line, near Clemson. SC St Rt 28 passes through the following towns in Oconee County Line. Mountain Rest Walhalla West Union Avondale Seneca
A guide marker on EB U.S. Rt. 76. A junction marker on EB U.S. Rt. 76/NB U.S. Rt. 123. WB U.S. Rt. 76/SC St Rt 28; SB U.S. Rt. 123 at SC St Rt 130. A guide marker on SB SC St Rt 130. EB U.S. Rt. 76/SC St Rt 28; NB U.S. Rt. 123 east of Seneca. EB U.S. Rt. 76/SC St Rt 28; NB U.S. Rt. 123 west of Wells Highway. A guide marker on NB Wells Highway. EB U.S. Rt. 76/SC St Rt 28; NB U.S. Rt. 123 east of Wells Highway. EB U.S. Rt. 76/SC St Rt 28; NB U.S. Rt. 123 at SC St Rt 93. EB U.S. Rt. 76/SC St Rt 28; NB U.S. Rt. 123 east of SC St Rt 93. EB U.S. Rt. 76/SC St Rt 28; NB U.S. Rt. 123 at the Seneca River.