Roads of the Mid-South & West > Highways of the State of Missouri > U.S. Federal Highways of Missouri > U.S. Federal Route 61, Missouri > U.S. Federal Route 61; Cape Girardeau County, Missouri

U.S. Federal Route 61
Cape Girardeau County

U.S. Federal Route 61 runs north-south through Cape Girardeau County. Through this county, U.S. Rt. 61 cross back and fourth Interstate 55.
U.S. Rt. 61 passes through the following towns in Cape Girardeau County.
Old Appleton

Fruitland
Jackson

Cape Girardeau
U.S. Rt. 61 is multi-plexed in Cape Girardeau County.
BUSN. Loop I-55, from near Fruitland to Cape Girardeau.

Missouri State Route 34, from near Jackson to Cape Girardeau.

Interstate 55, from Cape Girardeau to the Cape Girardeau/Scott County Line.

U.S. Rt. 61 intersects the following highways in Cape Girardeau County.
Missouri Secondary State Route KK, near Old Appleton.

Missouri Secondary State Route CC, near Pocahontas.
Missouri Secondary State Route E, near Pocahontas.
Missouri Secondary State Route C, near Pocahontas.
Missouri Secondary State Route FF, at Fruitland.
Missouri State Route 177, near Fruitland.
Interstate 55, near Fruitland.
BUSN. Loop I-55, near Fruitland.
Missouri Secondary State Route Y, near Jackson.

Missouri Secondary State Route D, near Jackson.

Missouri State Route 25, at Jackson.
Missouri State Route 34, at Jackson.
Missouri State Route 72, at Jackson.

Interstate 55, at Cape Girardeau.
Missouri Secondary State Route W, at Cape Girardeau.
Missouri Secondary State Route K, at Cape Girardeau.
Missouri State Route 74, at Cape Girardeau.
Missouri State Route 34, at Cape Girardeau.

Interstate 55, at Cape Girardeau.
Missouri State Route 74, at Cape Girardeau.

NB U.S. Rt. 61 at Main Street in Old Appleton.

BGS on SB I-55.

SB BUSN Loop I-55/U.S. Rt. 61 near Jackson.

BGS on SB I-55.

NB BUSN Loop I-55/U.S. Rt. 61; WB MO St Rt 34 in Cape Girardeau.

Looking north at the intersection of U.S. Rt. 61/BUSN. Loop I-55 at Southern Expressway.
30 August 2026