Missouri State Route 74 runs east-west in Southeastern Cape Girardeau County. This highway runs from Dutchtown to the Missouri/Illinois State Line, via Cape Girardeau. MO St Rt 74 passes through the following towns in Cape Girardeau County. Dutchtown Cape Girardeau MO St Rt 74 is multi-plexed in Cape Girardeau County. Interstate 55, at Cape Giradeau.
Missouri State Route 177, at Cape Girardeau. Illinois State Route 146, at the Illinois/Missouri State Line.
A BGS on SB I-55. A BGS on SB I-55/WB MO St Rt 74. EB MO St Rt 34/74 in Cape Girardeau. EB MO St Rt 34/74 near the Mississippi River. EB MO St Rt 34/74 crossing the Mississippi River.