Missouri State Route 34 is one of the main east-west highways in Central Cape Girardeau County. This highway runs through Downtown Cape Girardeau. MO St Rt 34 passes through the following towns in Cape Girardeau County. Cape Girardeau Jackson
MO St Rt 34 is multi-plexed in Cape Girardeau County. Missouri State Route 72, near Jackson. BUSN. Loop I-55, from near Jackson to Cape Girardeau. U.S. Rt. 61, from near Jackson to Cape Girardeau.